Scientific Innovation &
Advanced Process Chemistry
With 18,000 sq. ft. of research space, 9 specialized laboratories, and 20+ Ph.D. scientists, Chieron drives cutting-edge synthetic chemistry, biocatalysis, and non-infringing process design.
10 Core R&D Activities
Delivering robust, scalable, and non-infringing chemical routes from mg-scale scouting to validation tonnages.
Develop robust and scalable processes for APIs, Intermediates & Specialty products with the highest grade of quality.
Developing non-infringing processes & identifying/exploring patent-fencing opportunities to create IP assets.
All analytical activities strictly aligned with international regulatory guidelines or customer requirements.
Technology transfer of new processes to Validation scale with complete batch records.
Technical Package of new processes and technology containing detailed reaction kinetics & thermal data.
Technical reply to regulatory queries from EDQM, US-DMF, and international health agencies.
Technical Support to business development and global customers.
Complete support for filing DMF (US-DMF, CEP, Canada, Australia) and regulatory dossiers.
Identification and isolation of Genotoxic / non-genotoxic impurities in process & method development (TTC approach).
Detailed impurity profiling during development and in-house synthesis of all reference impurities and their characterization.
ADL – Analytical Development Laboratory
Conforming to ICH, USP, EP, FDA, WHO, and In-house SOP Guidelines.
Analytical Method Validation
Method development and validation for KSMs, in-process, intermediate, API, and cleaning verification samples.
Genotoxic & Nitrosamines
Carry-over studies of potential mutagenic impurities, nitrosamine trace analysis (LC-MS/MS), and risk assessments.
Impurity Fate Mapping & TPF
Theoretical Purge Factor (TPF) determination and spike-recovery studies across synthetic steps.
Compendial Equivalence
Verification of pharmacopoeial analytical methods (USP, EP, IP, JP) & method equivalence studies.
Stress & Forced Degradation
Forced degradation studies under thermal, photolytic, humidity, acidic, basic, and oxidation conditions.
Indicative Stability Studies
Real-time, accelerated, and photo-stability studies under diverse climatic conditions and packaging types.
Reference Standard Management
Primary and working standard qualification using HPLC/GC/TGA and NMR/IR/MS structure verification.
Impurity Isolation & Synthesis
Preparative HPLC isolation of unknown degradation products followed by spectroscopic structural characterization.
Intellectual Property Management (IPM)
Ensuring complete freedom to operate (FTO) and patent fencing for all synthesized molecules.
Core Roles
Innovation support, Infringement Screening, IP-Validation, Freedom-to-Operate (FTO) Analysis, Patent Drafting, Filing, and IP Alerts.
Databases & Tools
CAS SciFinder, USPTO, European Patent Office (EPO), WIPO, Scopus, PubMed, and global patent registries.
Talent Pool
Registered Indian Patent Agents with Organic Chemistry Postgraduates & Ph.Ds with 15+ years of techno-legal patent experience.
Data Security
ISO 9001 Quality Assurance, strict Non-Disclosure Agreements (NDAs), and Enterprise Data Security Software.
Green Chemistry Principles & Case Studies
Minimizing consumption of organic solvents, promoting water-based reactions, and employing biocatalysis for high atom economy.
Prevention of Toxic Chemicals
Toxic chemicals replaced with enzymatic biocatalysis
Eliminated hazardous heavy metal catalysts and reduced toxic solvent waste by 65%.
Ensuring Atom Economy
Maximizing incorporation of reactant atoms into final molecule
High atom efficiency, yielding minimal by-products and significantly lower E-factor.
Less Hazardous Chemical Syntheses
Designed synthesis - Replacement of pyrophoric chemicals with simple safe RMs
Eliminated pyrophoric reagents in scale-up, vastly enhancing operator safety and process consistency.
Designing Safer Chemicals & Solvents
Promoted water-based and green EHS-convenient reactions
Drastically reduced VOC emissions and hazardous organic solvent consumption.
Energy Efficiency, Waste Reduction & Catalysis
Lowering activation energy via homogeneous/heterogeneous catalysis
Optimized reaction kinetics, lowering thermal energy needs by 28%.
Telescopic & One-Pot Approach
Sequential reactions in a single vessel without isolating intermediate streams
Reduced solvent wash cycles, lowered cycle times, and maximized batch output.